Paper-based sperm DNA integrity analysis. Issue 33 (3rd August 2016)

• Record Type: Journal Article
• Authors: Nosrati, Reza; Gong, Max M.; San Gabriel, Maria C.; Zini, Armand; Sinton, David
• Is Part Of: Analytical methods. Volume 8:Issue 33(2016)
• Page Start: 6260
• Page End: 6264
• Publication Date: 2016-08-03
• Subjects: Chemistry, Analytic -- Periodicals; Analytical biochemistry -- Periodicals; Chemical laboratories -- Standards -- Periodicals; 543.1905
• DOI: 10.1039/c6ay01506a
• Languages: English
• ISSNs: 1759-9660

Abstract

Abstract : A comprehensive paper-based assay for sperm chromatin integrity analysis has been demonstrated that quantifies both DNA fragmentation and packaging. Abstract : We demonstrate a rapid, sensitive, and low cost paper-based approach for sperm chromatin integrity analysis that quantifies both DNA fragmentation and packaging. The paper-based test provides identical clinical outcome as the gold standard sperm chromatin structure assay. This technology is fast, simple, and suitable for broad application in clinics.