Mitochondria‐Targeting Magnetic Composite Nanoparticles for Enhanced Phototherapy of Cancer. Issue 33 (7th July 2016)

• Record Type: Journal Article
• Authors: Guo, Ranran; Peng, Haibao; Tian, Ye; Shen, Shun; Yang, Wuli
• Is Part Of: Small. Volume 12:Issue 33(2016)
• Page Start: 4541
• Page End: 4552
• Publication Date: 2016-07-07
• Subjects: magnetic composite nanoparticles -- mitochondria‐targeting -- multimode imaging -- photodynamic therapy -- photothermal therapy; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201601094
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Photothermal therapy (PTT) and photodynamic therapy (PDT) are promising cancer treatment modalities in current days while the high laser power density demand and low tumor accumulation are key obstacles that have greatly restricted their development. Here, magnetic composite nanoparticles for dual‐modal PTT and PDT which have realized enhanced cancer therapeutic effect by mitochondria‐targeting are reported. Integrating PTT agent and photosensitizer together, the composite nanoparticles are able to generate heat and reactive oxygen species (ROS) simultaneously upon near infrared (NIR) laser irradiation. After surface modification of targeting ligands, the composite nanoparticles can be selectively delivered to the mitochondria, which amplify the cancer cell apoptosis induced by hyperthermia and the cytotoxic ROS. In this way, better photo therapeutic effects and much higher cytotoxicity are achieved by utilizing the composite nanoparticles than that treated with the same nanoparticles missing mitochondrial targeting unit at a low laser power density. Guided by NIR fluorescence imaging and magnetic resonance imaging, then these results are confirmed in a humanized orthotropic lung cancer model. The composite nanoparticles demonstrate high tumor accumulation and excellent tumor regression with minimal side effect upon NIR laser exposure. Therefore, the mitochondria‐targeting composite nanoparticles are expected to be an effective phototherapeutic platform in oncotherapy. Abstract : Mitochondria‐targeting magnetic composite nanoparticles combining photothermal therapy and photodynamic therapy are prepared. Localized heat and reactive oxygen species are simultaneously generated by the mitochondria‐targeting nanoparticles under near infrared (NIR) laser irradiation. Guided by NIR fluorescence imaging and magnetic resonance imaging, photo therapy in a cancer model is conducted that reveals the outstanding therapeutic effect of the composite nanoparticles.