Traumatic Brain Injury Imaging in the Second Near‐Infrared Window with a Molecular Fluorophore. Issue 32 (2nd June 2016)

• Record Type: Journal Article
• Authors: Zhang, Xiao‐Dong; Wang, Huasen; Antaris, Alexander L.; Li, Lulin; Diao, Shuo; Ma, Rui; Nguyen, Andy; Hong, Guosong; Ma, Zhuoran; Wang, Joy; Zhu, Shoujun; Castellano, Joseph M.; Wyss‐Coray, Tony; Liang, Yongye; Luo, Jian; Dai, Hongjie
• Is Part Of: Advanced materials. Volume 28:Issue 32(2016)
• Page Start: 6872
• Page End: 6879
• Publication Date: 2016-06-02
• Subjects: molecular fluorophores -- near‐infrared II fluorescence imaging -- traumatic brain injury; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201600706
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. A bright, renal‐excreted, and biocompatible near‐infrared II fluorophore for in vivo imaging of TBI is designed. A transient hypoperfusion in the injured cerebral region, followed by fluorophore leakage, is observed. NIR‐II fluorophores can provide noninvasive assessment of TBI.