Synthesis of Ferromagnetic Fe0.6Mn0.4O Nanoflowers as a New Class of Magnetic Theranostic Platform for In Vivo T1‐T2 Dual‐Mode Magnetic Resonance Imaging and Magnetic Hyperthermia Therapy. Issue 16 (14th June 2016)

• Record Type: Journal Article
• Authors: Liu, Xiao Li; Ng, Cheng Teng; Chandrasekharan, Prashant; Yang, Hai Tao; Zhao, Ling Yun; Peng, Erwin; Lv, Yun Bo; Xiao, Wen; Fang, Jie; Yi, Jia Bao; Zhang, Huan; Chuang, Kai‐Hsiang; Bay, Boon Huat; Ding, Jun; Fan, Hai Ming
• Is Part Of: Advanced healthcare materials. Volume 5:Issue 16(2016)
• Page Start: 2092
• Page End: 2104
• Publication Date: 2016-06-14
• Subjects: exchange coupling effect -- Fe0.6Mn0.4O nanoflowers -- magnetic hyperthermia -- magnetic resonance imaging -- T1‐T2 dual‐mode; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201600357
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Uniform wüstite Fe0.6 Mn0.4 O nanoflowers have been successfully developed as an innovative theranostic agent with T1 ‐T2 dual‐mode magnetic resonance imaging (MRI), for diagnostic applications and therapeutic interventions via magnetic hyperthermia. Unlike their antiferromagnetic bulk counterpart, the obtained Fe0.6 Mn0.4 O nanoflowers show unique room‐temperature ferromagnetic behavior, probably due to the presence of an exchange coupling effect. Combined with the flower‐like morphology, ferromagnetic Fe0.6 Mn0.4 O nanoflowers are demonstrated to possess dual‐modal MRI sensitivity, with longitudinal relaxivity r 1 and transverse relaxivity r 2 as high as 4.9 and 61.2 mm −1 s −1 [Fe]+[Mn], respectively. Further in vivo MRI carried out on the mouse orthotopic glioma model revealed gliomas are clearly delineated in both T1 ‐ and T2 ‐weighted MR images, after administration of the Fe0.6 Mn0.4 O nanoflowers. In addition, the Fe0.6 Mn0.4 O nanoflowers also exhibit excellent magnetic induction heating effects. Both in vitro and in vivo magnetic hyperthermia experimentation has demonstrated that magnetic hyperthermia by using the innovative Fe0.6 Mn0.4 O nanoflowers can induce MCF‐7 breast cancer cell apoptosis and a complete tumor regression without appreciable side effects. The results have demonstrated that the innovative Fe0.6 Mn0.4 O nanoflowers can be a new magnetic theranostic platform for in vivo T1 ‐T2 dual‐mode MRI and magnetic thermotherapy, thereby achieving a one‐stop diagnosis cum effective therapeutic modality in cancer management. Abstract : Room‐temperature ferromagnetic Fe0.6 Mn0.4 O nanoflowers synthesized by the facile one‐pot high‐temperature thermal decomposition method, have been successfully developed as an innovative theranostic agent with in vivo T1 ‐T2 dual‐mode magnetic resonance imaging for diagnostic applications and therapeutic interventions via magnetic hyperthermia. It provides a new optimization strategy of the composition and structure of magnetic nanoparticles for multimodality cancer diagnostics and therapy.