A Novel Peptide Hydrogel for an Antimicrobial Bandage Contact Lens. Issue 16 (8th June 2016)

• Record Type: Journal Article
• Authors: Gallagher, Andrew G.; Alorabi, Jamal A.; Wellings, Donald A.; Lace, Rebecca; Horsburgh, Mal J.; Williams, Rachel L.
• Is Part Of: Advanced healthcare materials. Volume 5:Issue 16(2016)
• Page Start: 2013
• Page End: 2018
• Publication Date: 2016-06-08
• Subjects: antimicrobial -- bandage lens -- cornea -- drug delivery -- hydrogel; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201600258
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : A peptide hydrogel with an antimicrobial activity is developed as a bandage contact lens. The antimicrobial activity is enhanced with the addition of the biomolecules penicillin G or poly‐ε‐lysine and is positive against Staphylococcus aureus and Escherichia coli . The lens is also noncytotoxic toward a human corneal epithelial cell line and as a consequence is of great potential as a drug‐eluting bandage lens replacing conventional corneal ulcer treatment.