Study on the frequency and risk factors of moderate-to-severe sleep apnea syndrome in rheumatoid arthritis. Issue 5 (2nd September 2016)

• Record Type: Journal Article
• Authors: Mutoh, Tomoyuki; Okuda, Yasuaki; Mokuda, Sho; Sawada, Naoya; Matoba, Kenichiro; Yamada, Akihiro; Jouyama, Kazuo; Onishi, Makoto; Takasugi, Kiyoshi
• Is Part Of: Modern rheumatology. Volume 26:Issue 5(2016)
• Page Start: 681
• Page End: 684
• Publication Date: 2016-09-02
• Subjects: Frequency -- HAQ-DI -- RA -- Sleep apnea syndrome -- Temporomandibular joint; Rheumatology -- Periodicals; 616.723005
• DOI: 10.3109/14397595.2015.1131352
• Languages: English
• ISSNs: 1439-7595

Abstract

Abstract: Objectives : We aimed to investigate the frequency of moderate-to-severe sleep apnea syndrome (SAS) that possibly influences long-term prognosis in patients with rheumatoid arthritis (RA), and to analyze the risk factors for this group. Methods : We examined respiratory disturbance index (RDI) by polysomnography in 62 hospitalized RA patients. Risk factors of moderate-to-severe SAS (RDI ≥20) were analyzed using a multivariate logistic regression analysis. Results : RA was complicated by moderate-to-severe SAS in 13/62 (20.9%) cases. The highest stage of temporomandibular joint abnormality (TMJA) and a high value of health assessment questionnaire-disability index (HAQ-DI) were significant risk factors, according to the results of the multivariate logistic regression analysis ( p < 0.0001 and p = 0.010, respectively). Contrary to these results, RDI was not related to the disease activity indexes of RA and other clinical characteristics. Conclusion : We clarified that the highest TMJA stage and a high value of HAQ-DI are novel important risk factors for moderate-to-severe SAS in RA patients.