Impaired auditory evoked potentials and oscillations in frontal and auditory cortex of a schizophrenia mouse model. (17th August 2016)

• Record Type: Journal Article
• Authors: Shahriari, Yalda; Krusienski, Dean; Dadi, Yamini Sureka; Seo, Misun; Shin, Hee-Sup; Choi, Jee Hyun
• Is Part Of: World journal of biological psychiatry. Volume 17:Number 6(2016)
• Page Start: 439
• Page End: 448
• Publication Date: 2016-08-17
• Subjects: Schizophrenia -- mouse -- auditory-steady-state-response -- EEG -- oscillations; Biological psychiatry -- Periodicals; Biological Psychiatry -- Periodicals; 616.89
• DOI: 10.3109/15622975.2015.1112036
• Languages: English
• ISSNs: 1562-2975

Abstract

Abstract: Objectives : In patients with schizophrenia, γ-band (30–70 Hz) auditory steady-state electroencephalogram responses (ASSR) are reduced in power and phase locking. Here, we examined whether γ-ASSR deficits are also present in a mouse model of schizophrenia, whose behavioural changes have shown schizophrenia-like endophenotypes. Methods : Electroencephalogram in frontal cortex and local field potential in primary auditory cortex were recorded in phospholipase C β1 (PLC-β1) null mice during auditory binaural click trains at different rates (20–50 Hz), and compared with wild-type littermates. Results : In mutant mice, the ASSR power was reduced at all tested rates. The phase locking in frontal cortex was reduced in the β band (20 Hz) but not in the γ band, whereas the phase locking in auditory cortex was reduced in the γ band. The cortico-cortical connectivity between frontal and auditory cortex was significantly reduced in mutant mice. Conclusions : The tested mouse model of schizophrenia showed impaired electrophysiological responses to auditory steady state stimulation, suggesting that it could be useful for preclinical studies of schizophrenia".