Celery root extract as an inducer of mania induction in a patient on venlafaxine and St John's Wort. Issue 7 (2nd October 2016)

• Record Type: Journal Article
• Authors: Khalid, Zaira; Osuagwu, Ferdnand C.; Shah, Bilal; Roy, Nikita; Dillon, James E.; Bradley, Ronald
• Is Part Of: Postgraduate medicine. Volume 128:Issue 7(2016)
• Page Start: 682
• Page End: 683
• Publication Date: 2016-10-02
• Subjects: Celery root -- mania -- venlafaxine -- St John's worth -- bipolar disorder; Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610.5
• DOI: 10.1080/00325481.2016.1218263
• Languages: English
• ISSNs: 0032-5481

Abstract

ABSTRACT: Celery root belongs to a group of plants classified as the umbelliferous family, which contains phytoestrogens. Phytoestrogens are structurally similar to estrogen as they share a pair of hydroxyl groups and phenolic ring, which enables them to bind to estrogen receptors directly, making them a herbal remedy for low estrogen states such as menopause. We present a case of a female patient with depression who was stabilized on venlafaxine and St John's Wort, and who developed a manic episode due to elevated serum venlafaxine levels after she started taking celery extracts for menopausal related issues. We proffer a hypothesis for this unusual occurrence.