Impulse control disorder in PD: A lateralized monoaminergic frontostriatal disconnection syndrome?. (September 2016)

• Record Type: Journal Article
• Authors: Premi, E.; Pilotto, A.; Garibotto, V.; Bigni, B.; Turrone, R.; Alberici, A.; Cottini, E.; Poli, L.; Bianchi, M.; Formenti, A.; Cosseddu, M.; Gazzina, S.; Magoni, M.; Bertoli, M.; Paghera, B.; Borroni, B.; Padovani, A.
• Is Part Of: Parkinsonism & related disorders. Volume 30(2016)
• Page Start: 62
• Page End: 66
• Publication Date: 2016-09
• Subjects: Parkinson's disease -- Impulse control disorders -- 123I-FP-CIT imaging -- Statistical parametric mapping -- Functional covariance analysis; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2016.05.028
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Background: Impulse Control Disorder symptoms (ICD) in Parkinson's disease (PD) has been recently associated by magnetic Resonance imaging with impaired cortico-striatal connectivity, especially between left putamen and frontal associative areas. Methods: 84 patients entered the study (21 PD-ICD+ and 64 PD-ICD-) and underwent DATSCAN imaging. The striatal tracer uptake was evaluated using BRASS software (Hermes, Sweden). The whole-brain analysis was performed with Statistical Parametric Mapping (SPM). Results: PD-ICD+ showed a significant reduction of left putaminal and left inferior frontal gyrus tracer uptake compared to PD-ICD-. Functional covariance analysis using left putamen as the seed point showed that, in contrast to ICD-patients, ICD+ patients had no functional covariance with contralateral basal ganglia and ipsilateral cingulate cortex, as index of an impaired inter- and intra-hemispheric dopamine binding in PD-ICD+. Discussion: the results support and expand the concept of a functional disconnection syndrome linked to ICD symptoms in PD patients through an asymmetric molecular frontostriatal network breakdown with left basal ganglia as central hub. Highlights: We studied Impulse Control Disorder (ICD) in Parkinson's disease. We evaluated striatal and extrastriatal DATSCAN uptake. PD-ICD + showed a significant reduction in left putamen and left inferior frontal gyrus. Impairment of inter- and intra-hemispheric binding in PD-ICD + patients was evident. Left basal ganglia was key in an asymmetric molecular frontostriatal network breakdown.