Dengue Virus Immunopathogenesis: Lessons Applicable to the Emergence of Zika Virus. Issue 17 (28th August 2016)

• Record Type: Journal Article
• Authors: Olagnier, David; Amatore, Donatella; Castiello, Luciano; Ferrari, Matteo; Palermo, Enrico; Diamond, Michael S.; Palamara, Anna Teresa; Hiscott, John
• Is Part Of: Journal of molecular biology. Volume 428:Issue 17(2016:Sep. 01)
• Page Start: 3429
• Page End: 3448
• Publication Date: 2016-08-28
• Subjects: dengue -- Zika -- innate immunity -- oxidative stress -- pathogenesis; DENV dengue virus -- DF dengue fever -- ZIKV Zika virus -- DHF dengue hemorrhagic fever -- ADE antibody-dependent enhancement -- FcγR Fcγ receptor -- WNV West Nile virus -- ROS reactive oxygen species -- RNS reactive nitrogen species -- GSH glutathione -- Mo-DCs monocyte-derived dendritic cells -- Nrf2 factor nuclear factor-erythroid 2-related factor 2 -- HO-1 heme oxygenase-1 -- PRRs pattern recognition receptors -- PAMPs pattern-associated molecular patterns -- DCs dendritic cells -- DC-SIGN DC-specific ICAM-3 grabbing non-integrin -- ER endoplasmic reticulum -- IFN interferon; Molecular biology -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Bacteriology -- Periodicals; Molecular Biology -- Periodicals; Biochemistry -- Periodicals; Biologie moléculaire -- Périodiques; Biologie -- Périodiques; Biochimie -- Périodiques; Moleculaire biologie; Biochemistry; Biology; Molecular biology; Periodicals; 572.805
• DOI: 10.1016/j.jmb.2016.04.024
• Languages: English
• ISSNs: 0022-2836

Abstract

Abstract: Dengue is the leading mosquito-transmitted viral infection in the world. There are more than 390 million new infections annually; while the majority of infected individuals are asymptomatic or develop a self-limited dengue fever, up to 1 million clinical cases develop severe manifestations, including dengue hemorrhagic fever and shock syndrome, resulting in ~ 25, 000 deaths annually, mainly in children. Gaps in our understanding of the mechanisms that contribute to dengue infection and immunopathogenesis have hampered the development of vaccines and antiviral agents. Some of these limitations are highlighted by the explosive re-emergence of another arthropod-borne flavivirus—Zika virus—spread by the same vector, the Aedes aegypti mosquito, that also carries dengue, yellow fever and chikungunya viruses. This review will discuss the early virus–host interactions in dengue infection, with emphasis on the interrelationship between oxidative stress and innate immune pathways, and will provide insight as to how lessons learned from dengue research may expedite therapeutic strategies for Zika virus. Graphical abstract: Highlights: Dengue is the leading mosquito-transmitted viral infection in the world. Severe manifestations of dengue include plasma leakage and coagulation dysfunction. The arthropod-borne Zika virus has spread rapidly, with the complication of microcephaly in newborns. This review examines how dengue research may expedite therapeutic strategies for Zika virus.