Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine. Issue 8 (18th August 2016)

• Record Type: Journal Article
• Authors: Liu, Kai; Yu, Chen; Xie, Min; Li, Ke; Ding, Sheng
• Is Part Of: Cell chemical biology. Volume 23:Issue 8(2016)
• Page Start: 893
• Page End: 916
• Publication Date: 2016-08-18
• Subjects: Biochemistry -- Periodicals; 572.05
• DOI: 10.1016/j.chembiol.2016.07.007
• Languages: English
• ISSNs: 2451-9456

Abstract

Abstract : Regenerative medicine aims to repair and regenerate injured tissues and restore their impaired functions. Recent developments in stem cell biology have attracted significant interest in their applications in regenerative medicine. Chemical approaches using small molecules have yielded exciting results in induction and differentiation of pluripotent stem cells, lineage conversion of somatic cells, and ex vivo as well as in vivo modulation of adult stem cells. In this review, we discuss recent progress, new insights, and future challenges of the chemical approaches in stem cell biology and regenerative medicine. Abstract : Stem cell therapy and regenerative medicine are both hotly debated topics, and therapies in these two related areas are much anticipated. Liu et al. review chemical approaches that are accelerating advances in this area, both when they are used as probes, to better understand basic biology, and as options for clinical interventions.