Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors12. Issue 8 (7th July 2016)

• Record Type: Journal Article
• Authors: Li, Yu; Xia, Guiquan; Guo, Qi; Wu, Li; Chen, Shizhen; Yang, Zhigang; Wang, Wei; Zhang, Zhong-Yin; Zhou, Xin; Jiang, Zhong-Xing
• Is Part Of: MedChemComm. Volume 7:Issue 8(2016:Aug.)
• Page Start: 1672
• Page End: 1680
• Publication Date: 2016-07-07
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19
• DOI: 10.1039/c6md00277c
• Languages: English
• ISSNs: 2040-2503

Abstract

Abstract : The first 19 F MRI sensitive PTP inhibitors were discovered. ortho -Bis(trifluoromethyl)carbinol phenol not only mimics the interactions between salicylic acid and PTPs, but sheds new light on PTPs. Abstract : Fluorine is a highly attractive element for both medicinal chemistry and imaging technologies. To facilitate protein tyrosine phosphatase (PTP)-targeted drug discovery and imaging-guided PTP research on fluorine, several highly potent and 19 F MR sensitive PTP inhibitors were discovered through a structure-based focused library strategy.