Design, synthesis and antiproliferative activity studies of 1, 2, 3-triazole–chalcones12. Issue 8 (5th July 2016)

• Record Type: Journal Article
• Authors: Fu, Dong-Jun; Zhang, Sai-Yang; Liu, Ying-Chao; Yue, Xiao-Xin; Liu, Jun-Ju; Song, Jian; Zhao, Ruo-Han; Li, Feng; Sun, Hui-Hui; Zhang, Yan-Bing; Liu, Hong-Min
• Is Part Of: MedChemComm. Volume 7:Issue 8(2016:Aug.)
• Page Start: 1664
• Page End: 1671
• Publication Date: 2016-07-05
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19
• DOI: 10.1039/c6md00169f
• Languages: English
• ISSNs: 2040-2503

Abstract

Abstract : 12k exhibited an IC50 value of 1.53 μM against SK-N-SH cells by inducing apoptosis and arresting the cell cycle at the G1 phase. Abstract : A series of 1, 2, 3-triazole–chalcone hybrids were designed, synthesized and evaluated for their antiproliferative activity against three selected cancer cell lines (SK-N-SH, HepG-2 and MGC-803). Most of the synthesized compounds exhibited moderate to good activity against all the cancer cell lines selected. Particularly, compound12k showed the most excellent antiproliferative activity with an IC50 value of 1.53 μM against SK-N-SH cancer cells. The mechanism studies revealed that compound12k inhibited the proliferation of SK-N-SH cancer cells by inducing apoptosis and arresting the cell cycle at the G1 phase.