The biogenic amine transporter activity of vinylogous amphetamine analogs12. Issue 8 (30th June 2016)

• Record Type: Journal Article
• Authors: Decker, Ann M.; Partilla, John S.; Baumann, Michael H.; Rothman, Richard B.; Blough, Bruce E.
• Is Part Of: MedChemComm. Volume 7:Issue 8(2016:Aug.)
• Page Start: 1657
• Page End: 1663
• Publication Date: 2016-06-30
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19
• DOI: 10.1039/c6md00245e
• Languages: English
• ISSNs: 2040-2503

Abstract

Abstract : Vinylogous amphetamine analog S -6 is a potent dual dopamine/serotonin (DA/5-HT) releaser with no activity at 5-HT2 receptors. Abstract : A series of vinylogous amphetamine analogs was synthesized and examined for their activity at biogenic amine transporters and serotonin-2 receptor (5-HT2 ) subtypes. (1 S, 3 E )-1-Methyl-4-phenyl-but-3-enylamine ( S -6 ) is a potent dual dopamine/serotonin (DA/5-HT) releaser with no activity at 5-HT2 receptors. This unique profile of actions suggests that analog S -6 is a viable lead compound for identifying new structural classes of DA/5-HT releasers with therapeutic benefit and reduced abuse liability.