Direct and metal-free oxidative amination of sp3 C–H bonds for the construction of 2-hetarylquinazolin-4(3H)-ones. Issue 9 (13th July 2016)

• Record Type: Journal Article
• Authors: Liu, Huanhuan; Zhai, Tianran; Ding, Shiteng; Hou, Yalei; Zhang, Xiangyu; Feng, Lei; Ma, Chen
• Is Part Of: Organic chemistry frontiers. Volume 3:Issue 9(2016:Sep.)
• Page Start: 1096
• Page End: 1099
• Publication Date: 2016-07-13
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c6qo00231e
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : New method for synthesis of 2-hetarylquinazolin-4(3 H )-ones from 2-aminobenzamides and (2-azaaryl)methanes under transition-metal free conditions, featuring a wide substrate scope with a broad range of functional group tolerance under mild conditions. Abstract : A new method for the synthesis of 2-hetarylquinazolin-4(3 H )-ones from 2-aminobenzamides and (2-azaaryl)methanes under transition metal-free conditions is described. This protocol features a wide substrate scope with a broad range of functional group tolerance under mild conditions. The oxidation of (2-azaaryl)methanes to (2-azaaryl)methanals is proposed as the key step in this transformation.