Novel benzo-bis(1, 2, 5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer. Issue 9 (22nd June 2016)

• Record Type: Journal Article
• Authors: Sun, Yao; Qu, Chunrong; Chen, Hao; He, Maomao; Tang, Chu; Shou, Kangquan; Hong, Suhyun; Yang, Meng; Jiang, Yuxin; Ding, Bingbing; Xiao, Yuling; Xing, Lei; Hong, Xuechuan; Cheng, Zhen
• Is Part Of: Chemical science. Volume 7:Issue 9(2016:Sep.)
• Page Start: 6203
• Page End: 6207
• Publication Date: 2016-06-22
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6sc01561a
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : Optical imaging of diseases represents a highly dynamic and multidisciplinary research area, and second near-infrared window (NIR-II, 1000–1700 nm) imaging is at the forefront of the research on optical imaging techniques. Abstract : Optical imaging of diseases represents a highly dynamic and multidisciplinary research area, and second near-infrared window (NIR-II, 1000–1700 nm) imaging is at the forefront of the research on optical imaging techniques. Small-molecule based NIR-II (1000–1700 nm) dyes are highly promising candidates for in vivo molecular imaging because of their high biocompatibility, fast excretion, and high clinical translation ability. However, research reports on small-molecule based NIR-II dyes and probes are rare. Herein, we designed a series of fluorescent compounds (Q1, Q2, Q3, andQ4 ) and investigated the relationships between their structures and absorption/fluorescence properties.Q4 (maximum emission at 1100 nm) stood out as the dye with the best physical properties and thus was selected as a scaffold for the facile construction of two types of water-soluble and biocompatible NIR-II probes (Q4NPs andSCH1100 ). Highly specific gastrin-releasing peptide receptor (GRPR) targeted NIR-II imaging of prostate cancer in living mice was achieved using the small-molecule probeSCH1100, which represents the first small peptide based NIR-II probe for targeted cancer imaging. The attractive imaging properties ofQ4 -based NIR-II probes open up many opportunities for molecular imaging and clinical translation in the unique NIR-II window.