Effect of Disease Pathologies on Transporter Expression and Function. (July 2016)

• Record Type: Journal Article
• Authors: Atilano‐Roque, Amandla; Roda, Gavriel; Fogueri, Uma; Kiser, Jennifer J.; Joy, Melanie S.
• Other Names: Arya Vikram guestEditor.; Kiser Jennifer J. guestEditor.
• Is Part Of: Journal of clinical pharmacology. Volume 56(2016)Supplement 7
• Page Start: S205
• Page End: S221
• Publication Date: 2016-07
• Subjects: brain -- kidney disease -- liver disease -- transporters; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Pharmacology, Clinical -- Periodicals; 615.1
• DOI: 10.1002/jcph.768
• Languages: English
• ISSNs: 0091-2700

Abstract

Abstract: Transporters are important determinants of drug absorption, distribution, and excretion. The clinical relevance of drug transporters in drug disposition and toxicology depends on their localization in liver, kidney, and brain. There has been growing evidence regarding the importance of disease status on alterations in metabolizing enzymes and transporter proteins. This review focuses on uptake and efflux transporter proteins in liver, kidney, and brain and discusses mechanisms of altered transporter expression and function secondary to disease.