Phenyl trimethyl ammonium tribromide mediated robust one-pot synthesis of spiro-oxacycles – an economic route – stereoselective synthesis of oxaspirohexacyclodieneones. Issue 33 (1st August 2016)

• Record Type: Journal Article
• Authors: Sarkar, Debayan; Ghosh, Manoj Kumar; Rout, Nilendri
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 33(2016)
• Page Start: 7883
• Page End: 7898
• Publication Date: 2016-08-01
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob01116k
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : This paper entails the first recognition of Phenyl Trimethyl Ammonium Tribromide (PTAB) as an effective reagent for spiro-cyclizations proceeding via oxidative dearomatization. Abstract : This paper entails the first recognition of Phenyl Trimethyl Ammonium Tribromide (PTAB) as an effective reagent for spiro-cyclizations proceeding via oxidative dearomatization. The experiment exhibits economical, metal and ligand free one-pot accomplishment of these significant transformations. The described protocol presents the first generalised methodology of spiro-oxacycle synthesis which can be applied towards various directions. A stereoselective synthesis of oxa-spirocyclooxadieneones has been accomplished.