Bioconjugation – using selective chemistry to enhance the properties of proteins and peptides as therapeutics and carriers. Issue 34 (27th July 2016)

• Record Type: Journal Article
• Authors: Gunnoo, Smita B.; Madder, Annemieke
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 34(2016)
• Page Start: 8002
• Page End: 8013
• Publication Date: 2016-07-27
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob00808a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Both peptide and protein therapeutics are becoming increasingly important for treating a wide range of diseases. Functionalisation of these via site-selective chemical modification leads to enhancement of their therapeutic properties. Abstract : The pharmaceutical market has largely been dominated by small molecule drugs; however, larger biomolecules have recently become important contenders. Of these biomolecules, protein and peptide therapeutics are proving useful due to their often improved pharmacokinetic properties. In many circumstances, functionalisation of the protein or peptide therapeutics results in performance enhancement, and various methodologies are applied. In addition, introducing unnatural amino acids for structural reinforcement via chemical modification is also common. These strategies are discussed in this review.