Fully synthetic self-adjuvanting MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential cancer vaccines. Issue 72 (17th August 2016)

• Record Type: Journal Article
• Authors: Liu, Yonghui; Zhang, Wenpeng; He, Qianqian; Yu, Fan; Song, Tianbang; Liu, Tingting; Zhang, Zhenqing; Zhou, Jun; Wang, Peng George; Zhao, Wei
• Is Part Of: Chemical communications. Volume 52:Issue 72(2016)
• Page Start: 10886
• Page End: 10889
• Publication Date: 2016-08-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc04623a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We have designed and synthesized MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential self-adjuvanting cancer vaccines using a linear solid phase peptide synthesis strategy. Abstract : We have designed and synthesized MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential self-adjuvanting cancer vaccines using a linear solid phase peptide synthesis strategy. These vaccine candidates have elicited T cell dependent immune response and the induced antibodies showed intense specific binding affinity to human MCF-7 cells.