Autophagosome–lysosome fusion: PIs to the rescue. (20th July 2016)
- Record Type:
- Journal Article
- Title:
- Autophagosome–lysosome fusion: PIs to the rescue. (20th July 2016)
- Main Title:
- Autophagosome–lysosome fusion: PIs to the rescue
- Authors:
- Li, Linsen
Zhong, Qing - Abstract:
- Abstract : Phosphoinositides (PIs), a small fraction of the cellular lipids, function in almost all cellular physiological processes and especially in intracellular membrane trafficking events. PIs play a critical role in autophagy, but only PI(3)P is well studied. In this issue of The EMBO Journal, Hasegawa et al (2016) identified INPP5E, an inositol polyphosphate 5‐phosphatase, as a novel regulator of autophagy. INPP5E controls the level of PI(3, 5)P2 at the lysosome and thereby locally regulates the actin cytoskeleton and autophagosome–lysosome fusion. Abstract : Phosphoinositide 5‐phosphatase INPP5E, one of the genes responsible for Joubert syndrome, decreases phosphatidylinositol 3, 5‐bisphosphate at lysosomes and thereby regulates autophagosome–lysosome fusion, a process that is disrupted in the presence of disease‐associated INPP5E mutations.
- Is Part Of:
- EMBO journal. Volume 35:Number 17(2016)
- Journal:
- EMBO journal
- Issue:
- Volume 35:Number 17(2016)
- Issue Display:
- Volume 35, Issue 17 (2016)
- Year:
- 2016
- Volume:
- 35
- Issue:
- 17
- Issue Sort Value:
- 2016-0035-0017-0000
- Page Start:
- 1845
- Page End:
- 1847
- Publication Date:
- 2016-07-20
- Subjects:
- Molecular biology -- Periodicals
572.805 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.15252/embj.201695134 ↗
- Languages:
- English
- ISSNs:
- 0261-4189
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3733.085000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 911.xml