SPATA2 – Keeping the TNF signal short and sweet. (28th July 2016)

• Record Type: Journal Article
• Authors: Feltham, Rebecca; Webb, Andrew I; Silke, John
• Is Part Of: EMBO journal. Volume 35:Number 17(2016)
• Page Start: 1848
• Page End: 1850
• Publication Date: 2016-07-28
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201695061
• Languages: English
• ISSNs: 0261-4189

Abstract

Abstract : In this issue of The EMBO Journal, a multi‐layered global proteome resource, which comprehensively covers TNF‐induced phosphorylation and ubiquitination events as well as receptor interactions, has led to identification of SPATA2 as a novel player that contributes to TNF signalling by interacting with the LUBAC ubiquitin ligase and the CYLD deubiquitylase. Loss of SPATA2 augments transcriptional activation of NF‐κB and limits TNF‐induced necroptosis. A separate screen published in EMBO Reports corroborates these findings by showing that SPATA2 deficiency regulates CYLD activity, TNF‐induced NF‐κB signalling and cell death. Abstract : Recent work published in The EMBO Journal and EMBO Reports yielded identification of SPATA2 as a novel player in TNF signalling, which interacts with the LUBAC ubiquitin ligase and the CYLD deubiquitylase. Loss of SPATA2 augments transcriptional activation of NF‐κB and limits TNF‐induced necroptosis.