A diagnostic approach to mild bleeding disorders. (27th June 2016)

• Record Type: Journal Article
• Authors: Boender, J.; Kruip, M. J. H. A.; Leebeek, F. W. G.
• Is Part Of: Journal of thrombosis and haemostasis. Volume 14:Number 8(2016:Aug.)
• Page Start: 1507
• Page End: 1516
• Publication Date: 2016-06-27
• Subjects: bleeding disorder -- bleeding score -- blood coagulation disorders -- diagnosis -- DNA sequencing -- hemostasis; Thrombosis -- Periodicals; Hemostasis -- Periodicals; Blood coagulation disorders -- Periodicals; 616.1
• DOI: 10.1111/jth.13368
• Languages: English
• ISSNs: 1538-7933

Abstract

Summary: Mild inherited bleeding disorders are relatively common in the general population. Despite recent advances in diagnostic approaches, mild inherited bleeding disorders still pose a significant diagnostic challenge. Hemorrhagic diathesis can be caused by disorders in primary hemostasis (von Willebrand disease, inherited platelet function disorders), secondary hemostasis (hemophilia A and B, other (rare) coagulant factor deficiencies) and fibrinolysis, and in connective tissue or vascular formation. This review summarizes the currently available diagnostic methods for mild bleeding disorders and their pitfalls, from structured patient history to highly specialized laboratory diagnosis. A comprehensive framework for a diagnostic approach to mild inherited bleeding disorders is proposed.