Author's View:Kinase joins the chaperone club: Androgen-regulated kinome reveals choline kinase alpha as a potential drug target in prostate cancer. (3rd May 2016)

• Record Type: Journal Article
• Authors: Asim, Mohammad; Massie, Charlie E.; Neal, David E.
• Is Part Of: Molecular & cellular oncology. Volume 3:Number 3(2016)
• Publication Date: 2016-05-03
• Subjects: Androgen Receptor -- chaperones -- therapeutic target -- prostate cancer; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2016.1140262
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: To identify clinically relevant downstream effectors of androgen signaling, the androgen-regulated kinome was defined in prostate cancer (PCa). Within this study, choline kinase α (CHKA) was identified as an androgen receptor chaperone that is both a biomarker of progression and a potential therapeutic target for PCa.