Delphinidin prevents disuse muscle atrophy and reduces stress-related gene expression*. Issue 8 (2nd August 2016)

• Record Type: Journal Article
• Authors: Murata, Motoki; Kosaka, Reia; Kurihara, Kana; Yamashita, Shuya; Tachibana, Hirofumi
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 80:Issue 8(2016)
• Page Start: 1636
• Page End: 1640
• Publication Date: 2016-08-02
• Subjects: Delphinidin -- muscle atrophy -- Cbl-b; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2016.1184560
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract : Delphinidin is a member of the anthocyanidin class of plant pigments. We examined the effects of delphinidin on muscle atrophy. Oral administration of delphinidin suppressed the muscle weight loss induced by mechanical unloading. Microarray analysis showed that delphinidin suppresses the upregulation of oxidative stress-related gene expression, including the expression of Cbl-b. Thus, delphinidin may prevent unloading-mediated muscle atrophy.