Synthesis, crystal structures, antioxidant activities, and DNA-binding studies of two silver(I) complexes with 1, 3-bis(1-ethylbenzimidazol-2-yl)-2-thiapropane, and α, β-unsaturated carboxylates. Issue 6 (18th March 2016)

• Record Type: Journal Article
• Authors: Wu, Huilu; Yang, Zaihui; Chen, Chengyong; Zhang, Jiawen; Zhang, Han; Peng, Hongping; Wang, Fei
• Is Part Of: Journal of coordination chemistry. Volume 69:Issue 6(2016)
• Page Start: 1076
• Page End: 1087
• Publication Date: 2016-03-18
• Subjects: Benzimidazole -- silver(I) complex -- crystal structures -- DNA-binding -- antioxidant activity; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2016.1145212
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: Two new ternary complexes of silver(I) with 1, 3-bis(1-ethylbenzimidazol-2-yl)-2-thiapropane (bebt) and two · α, β -unsaturated carboxylates, [Ag(bebt)(crotonate)] (1 ) and [Ag(bebt)2 ](o-coumarate)·CH3 CN·2C2 H5 OH (2 ), have been synthesized, and characterized by physicochemical and spectroscopic methods. Single-crystal X-ray diffraction revealed that the coordination environment of1 can be described as trigonal planar, while2 has a distorted tetrahedral geometry. Experimental studies of the DNA-binding properties indicated that the free ligand and both complexes bind to DNA via intercalation, and the order of the binding affinity is1 > bebt > 2 . Antioxidant activity experiments show that2 possesses significant antioxidant activity against hydroxyl radicals, with more efficient hydroxy radical scavenging compared with mannitol and vitamin C. Abstract :