Highly efficient and scalable chemoenzymatic syntheses of (R)- and (S)-lactaldehydes. Issue 2 (6th November 2015)

• Record Type: Journal Article
• Authors: Vogel, M. A. K.; Burger, H.; Schläger, N.; Meier, R.; Schönenberger, B.; Bisschops, T.; Wohlgemuth, R.
• Is Part Of: Reaction chemistry & engineering. Volume 1:Issue 2(2016)
• Page Start: 156
• Page End: 160
• Publication Date: 2015-11-06
• Subjects: Reaction mechanisms (Chemistry) -- Periodicals; Chemical engineering -- Periodicals; Chemical engineering; Reaction mechanisms (Chemistry); Periodicals; 547.705
• DOI: 10.1039/c5re00009b
• Languages: English
• ISSNs: 2058-9883

Abstract

Abstract : Biocatalytic asymmetric reductions have been key steps in the synthesis of 1, 1-dimethoxy-2-propanone, catalyzed by suitable ketoreductases to ( S )- and ( R )-1, 1-dimethoxy-2-propanol, obtained in ≥99.9% ee and excellent yield. Removal of the protecting group gave the ( S )- and ( R )-lactaldehydes in excellent yield and purity. Abstract : Biocatalytic asymmetric reductions have been key steps in the enantioselective reduction of 1, 1-dimethoxy-2-propanone, catalyzed by suitable ketoreductases, to enantiomerically pure ( S )- and ( R )-1, 1-dimethoxy-2-propanols, obtained in ≥99.9% ee and excellent yield. Removal of the protecting group gave the ( S )- and ( R )-lactaldehydes in high yield and excellent enantiomeric and chemical purity.