Cutaneous angiosarcoma mimicking xanthoma: a challenging histopathologic diagnosis with important consequences. (14th June 2016)

• Record Type: Journal Article
• Authors: Llamas‐Velasco, Mar; Kutzner, Heinz; Requena, Luis
• Is Part Of: Journal of cutaneous pathology. Volume 43:Number 9(2016)
• Page Start: 792
• Page End: 797
• Publication Date: 2016-06-14
• Subjects: angiosarcoma -- foamy cells -- immunohistochemistry; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616
• DOI: 10.1111/cup.12739
• Languages: English
• ISSNs: 0303-6987

Abstract

Abstract : Cutaneous angiosarcoma may show protean histopathologic features. Rare or uncommon variants include epithelioid, clear cell, granular cell, verrucous, pseudolymphomatous and signet‐ring cell types. Perhaps the rarest type consists of cutaneous angiosarcoma with xanthomization of neoplastic cells. We report an extraordinary case with almost all neoplastic cells exhibiting a xanthomatous appearance that was studied both histopathologically and immunohistochemically. We discuss the histopathologic differential diagnosis of foamy cell angiosarcoma with other neoplasms that may show similar histopathology.