Retinal vessel diameters in a Japanese population: the Locomotive Syndrome and Health Outcome in Aizu Cohort Study. (25th January 2016)

• Record Type: Journal Article
• Authors: Tano, Takatoshi; Ono, Koichi; Hiratsuka, Yoshimune; Otani, Koji; Sekiguchi, Miho; Konno, Shinichi; Kikuchi, Shinichi; Onishi, Yoshihiro; Takegami, Misa; Yamada, Masakazu; Fukuhara, Shunichi; Murakami, Akira
• Is Part Of: Acta ophthalmologica. Volume 94:Number 6(2016)
• Page Start: e432
• Page End: e441
• Publication Date: 2016-01-25
• Subjects: arteriole‐to‐venule ratio -- Japanese -- population‐based study -- retinal blood vessel diameter -- retinal fundus camera; Ophthalmology -- Periodicals; 617.7005
• DOI: 10.1111/aos.12953
• Languages: English
• ISSNs: 1755-375X

Abstract

Abstract: Purpose: To describe the relationship between retinal vascular calibre and cardiovascular risk factors in a Japanese population. Methods: The Locomotive Syndrome and Health Outcome in Aizu Cohort Study is a population‐based, cross‐sectional survey that included 2346 persons (56.1% of the eligible population) aged 40 to 74 years old. Retinal vascular calibre was measured from digital retinal photographs using a validated standardized protocol. Data on major cardiovascular risk factors were collected from all participants. Results: Of the 1787 participants with available retinal vascular calibre data, the mean retinal arteriolar calibre (CRAE) was 141.6 ± 18.6 μ m, the mean venular calibre (CRVE) was 209.3 ± 26.1 μ m, and the mean arteriole‐to‐venule ratio was 0.68 ± 0.08. A smaller CRAE was associated with male sex, increasing quartiles of systolic blood pressure and diastolic blood pressure, history of hypertension, current alcohol intake and higher quartiles of serum creatinine. A larger CRAE was associated with increasing quartiles of total cholesterol. A larger CRVE was associated with current cigarette smoking. Multivariate analyses showed that a smaller CRAE was associated with male sex, elevated mean arterial blood pressure and a history of hypertension; and a larger CRVE was associated with cigarette smoking. Conclusions: The results of this study suggest that a narrowed diameter of the retinal arteriole in Japanese people is related to hypertension and sex (male) and that an enlarged retina venular diameter is related to a history of smoking. The pattern of these associations is similar to that in white populations and other Asian populations.