Synthesis of polymeric nanocapsules by radical UV‐activated interface‐emulsion polymerization. Issue 20 (18th July 2016)

• Record Type: Journal Article
• Authors: Bazzano, Marco; Pisano, Roberto; Brelstaff, Jack; Spillantini, Maria Grazia; Sidoryk‐Wegrzynowicz, Marta; Rizza, Giancarlo; Sangermano, Marco
• Is Part Of: Journal of polymer science. Volume 54:Issue 20(2016)
• Page Start: 3357
• Page End: 3369
• Publication Date: 2016-07-18
• Subjects: core–shell nanocapsule -- curcumin -- drug‐delivery systems -- interface‐emulsion polymerization -- mini‐emulsion; 547
• DOI: 10.1002/pola.28226
• Languages: English
• ISSNs: 0887-624X

Abstract

ABSTRACT: A new methodology is reported that allows a better control of the synthesis of polymeric core–shell nanocapsules. These nanocapsules were made of biocompatible polymers, obtained from poly(ethylene glycol)diacrylate and poly(ethylene glycol) methyl ether methacrylate, and were used as carrier for curcumin as therapeutic agent. The impact of manufacturing factors (time of sonication, time of UV irradiation, and type of monomer) was investigated in relation to the average size of nanocapsules, their distribution, shape, composition, stability, and their capability to deliver curcumin. We successfully synthesized core–shell nanocapsules in various sizes, ranging from 80 nm to 300 nm, by acting either on the process conditions or on the composition of the monomer mixture. This wide range of sizes makes the method here proposed very promising for the production of nanocarriers. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem.2016, 54, 3357–3369 Abstract : This paper presents a new methodology, named interface‐emulsion polymerization, that allows a better control of the synthesis of polymeric core–shell nanocapsules, having a hydrophilic surface and a hydrophobic core. Core‐shell nanocapsules were successfully synthesized in various sizes, ranging from 80 nm to 300 nm, by acting either on the process conditions or on the composition of the monomer mixture.