Two New Ring A‐Cleaved Lanostane‐Type Triterpenoids and Four Known Steroids Isolated from Endophytic Fungus Glomerella sp. F00244. Issue 8 (1st August 2016)

• Record Type: Journal Article
• Authors: Guo, Kai; Fang, Huiqin; Gui, Fu; Wang, Yuezhou; Xu, Qinyan; Deng, Xianming
• Is Part Of: Helvetica chimica acta. Volume 99:Issue 8(2016:Aug.)
• Page Start: 601
• Page End: 607
• Publication Date: 2016-08-01
• Subjects: Triterpenoid -- Steroid -- Endophytic fungus -- Biogenesis -- Mevalonic acid pathway; Chemistry -- Periodicals; Chemistry, Analytical -- periodicals; Chimie -- Périodiques; 540
• DOI: 10.1002/hlca.201600039
• Languages: English
• ISSNs: 0018-019X

Abstract

Abstract : Two new ring A ‐cleaved lanostane‐type triterpenoids, glometenoid A (1 ) and glometenoid B (2 ), together with four known steroids, (20 S, 22 E, 24 R )‐ergosta‐7, 22‐dien‐3 β, 5 α, 6 β ‐triol (3 ), (3 β, 5 α, 8 α, 22 E )‐ergosta‐6, 22‐diene‐3, 5, 8‐triol (4 ), 5 α, 8 α ‐epidioxy‐22 E ‐ergosta‐6, 22‐dien‐3 β ‐ol (5 ), and ergosterol (6 ), were isolated from the endophytic fungus Glomerella sp. F00244. Their structures were elucidated by comprehensive spectroscopic analyses of NMR and MS data. Their antimicrobial activities were evaluated against pathogenic bacteria Bacillus subtilis ATCC 9372, Staphylococcus aureus ATCC 25923, Bacillus pumilus CMCC (B) 63202, Micrococcus luteus CMCC28001, and pathogenic fungi Candida albicans AS2.538 and Aspergillus niger ACCC30005, but no inhibition was observed at a concentration of 20 μg/ml. Further cytotoxicity assessment revealed that compound1 exhibited weak antiproliferative activity against ovarian cancer HeLa cell. Abstract :