Down‐expression of miR‐154 suppresses tumourigenesis in CD133+ glioblastoma stem cells. (24th June 2016)

• Record Type: Journal Article
• Authors: Yang, Liang; Yan, Zhongjie; Wang, Yuanyu; Ma, Wandong; Li, Chen
• Is Part Of: Cell biochemistry and function. Volume 34:Number 6(2016)
• Page Start: 404
• Page End: 413
• Publication Date: 2016-06-24
• Subjects: glioblastoma stem cells -- CD133 -- miR‐154 -- PRPS1 -- cell proliferation; Cytochemistry -- Periodicals; Cell metabolism -- Periodicals; Biochemistry -- Periodicals; Cytology -- Periodicals; 572
• DOI: 10.1002/cbf.3201
• Languages: English
• ISSNs: 0263-6484

Abstract

Abstract : Glioblastoma multiforme (GBM) is the most common and aggressive form of brain cancer. Evidences have suggested that CD133 is a marker for a subset of glioblastoma cancer stem cells. However, whether miRNA plays a critical role in CD133 + GBM is poorly understood. Here, we identified that miR‐154 was upregulated in CD133 + GBM cell lines. Knockdown of miR‐154 remarkably suppressed proliferation and migration of CD133 + GBM cells. Further study found that PRPS1 was a direct target of miR‐154 in CD133 + GBM cells. Overexpression of PRPS1 exhibited similar effects as miR‐154 knockdown in CD133 + GBMs. Our study identified miR‐154 as a previously unrecognized positive regulator of proliferation and migration in CD133 + GBM cells and a potentially therapeutic target of GBMs. Copyright © 2016 John Wiley & Sons, Ltd.