Functional innovation from changes in protein domains and their combinations. (June 2016)

• Record Type: Journal Article
• Authors: Lees, Jonathan G; Dawson, Natalie L; Sillitoe, Ian; Orengo, Christine A
• Is Part Of: Current opinion in structural biology. Volume 38(2016)
• Page Start: 44
• Page End: 52
• Publication Date: 2016-06
• Subjects: Molecular biology -- Periodicals; 570
• DOI: 10.1016/j.sbi.2016.05.016
• Languages: English
• ISSNs: 0959-440X

Abstract

Highlights: An update of recent papers on functional innovations with domains. Interplay between changes in a domains function and its interactors/domain partners. Comparative genomics to cancer genomic perspectives. Abstract : Domains are the functional building blocks of proteins. In this work we discuss how domains can contribute to the evolution of new functions. Domains themselves can evolve through various mechanisms, altering their intrinsic function. Domains can also facilitate functional innovations by combining with other domains to make novel proteins. We discuss the mechanisms by which domain and domain combinations support functional innovations. We highlight interesting examples where changes in domain combination promote changes at the domain level.