Successful treatment of multiple vemurafenib-induced keratoacanthomas by topical application of imiquimod cream: Confirmation of clinical clearance by dermoscopy. (2nd September 2016)

• Record Type: Journal Article
• Authors: Rhee, Do Young; Won, Kwang Hee; Lee, Ye Jin; Won, Chong Hyun; Chang, Sung Eun; Lee, Mi Woo
• Is Part Of: Journal of dermatological treatment. Volume 27:Number 5(2016:Oct.)
• Page Start: 448
• Page End: 449
• Publication Date: 2016-09-02
• Subjects: Vemurafenib -- keratoacanthomas -- imiquimod cream; Skin -- Diseases -- Treatment -- Periodicals; Skin Diseases -- drug therapy -- Periodicals; Skin Diseases -- therapy -- Periodicals; 616.5
• DOI: 10.3109/09546634.2015.1133886
• Languages: English
• ISSNs: 0954-6634

Abstract

Abstract: Keratoacanthomas (KAs) are a well-known cutaneous side effect of BRAF inhibitors and multiple lesions continue to develop throughout the course of therapy. We present a case of an 81-year old women diagnosed with metastatic melanoma who underwent six weeks of vemurafenib therapy. She developed multiple vemurafenib-induced KAs and applied a 5% imiquimod cream three times a week. KAs successfully treated with topical application of imiquimod cream and clearance of these lesions was further confirmed by dermoscopic examination. Topical imiquimod can be an effective treatment option for the noninvasive management of multiple KAs induced by vemurafenib treatment.