Catalytic Asymmetric Allylation of 3‐Aryloxindoles by Merging Palladium Catalysis and Asymmetric H‐Bonding Catalysis. Issue 16 (3rd August 2016)

• Record Type: Journal Article
• Authors: Boucherif, Amina; Duan, Shu‐Wen; Yuan, Zhi‐Guang; Lu, Liang‐Qiu; Xiao, Wen‐Jing
• Is Part Of: Advanced synthesis & catalysis. Volume 358:Issue 16(2016)
• Page Start: 2594
• Page End: 2598
• Publication Date: 2016-08-03
• Subjects: allylic alkylation reaction -- asymmetric H-bonding catalysis -- dual catalysis -- oxindoles -- palladium catalysis; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201501155
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A catalytic asymmetric allylic alkylation reaction of 3‐aryloxindoles was accomplished via a dual catalysis merging palladium catalysis and asymmetric H‐bonding catalysis for the first time. Using this approach, allylated oxindoles bearing chiral all‐carbon quaternary centers were produced in high yields with good enantioselectivities (up to 92 % yield and 96:4 er ). Abstract :