Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development. Issue 16 (14th July 2016)

• Record Type: Journal Article
• Authors: Omori, Hisayoshi; Ogaki, Soichiro; Sakano, Daisuke; Sato, Mutsumi; Umeda, Kahoko; Takeda, Naoki; Nakagata, Naomi; Kume, Shoen
• Is Part Of: FEBS letters. Volume 590:Issue 16(2016)
• Page Start: 2584
• Page End: 2593
• Publication Date: 2016-07-14
• Subjects: C2cd4 -- insulin -- pancreas -- pancreatic beta cell; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.12271
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : C2cd4c, encoded by a gene belonging to the C2cd4 family, contains a C2 domain conserved across species and is localized to the cytoplasm. To examine the role of C2cd4c in the pancreas, we studied its localization and generated C2cd4c knockout (KO) mice. C2cd4c was expressed in pancreatic endocrine progenitors at early embryonic stages. When endocrine cells arise from their precursors, C2cd4c is gradually confined to the insulin‐ and pancreatic polypeptide‐expressing cells of the endocrine. In the adult pancreas, C2cd4c is restricted to the beta cells. C2cd4c KO mice showed normal embryonic pancreatic development and adult pancreatic function. Thus, our results suggest that C2cd4c is dispensable for pancreatic development. Abstract :