A condition closely mimicking IgG4-related disease despite the absence of serum IgG4 elevation and IgG4-positive plasma cell infiltration. Issue 5 (2nd September 2016)

• Record Type: Journal Article
• Authors: Hara, Satoshi; Kawano, Mitsuhiro; Mizushima, Ichiro; Yamada, Kazunori; Fujita, Kentaro; Harada, Kenichi; Matsumura, Masami; Yamagishi, Masakazu; Sato, Yasuharu; Yamaguchi, Yutaka; Nakanuma, Yasuni; Nagata, Michio
• Is Part Of: Modern rheumatology. Volume 26:Issue 5(2016)
• Page Start: 784
• Page End: 789
• Publication Date: 2016-09-02
• Subjects: IgG4-related disease -- IgG4 -- Tubulointerstitial nephritis; Rheumatology -- Periodicals; 616.723005
• DOI: 10.3109/14397595.2014.916836
• Languages: English
• ISSNs: 1439-7595

Abstract

Abstract : We describe a 74-year-old Japanese man with systemic fibroinflammatory conditions closely resembling those of immunoglobulin G4-related disease (IgG4-RD). Radiology and histology showed characteristics of IgG4-related tubulointerstitial nephritis, despite normal serum IgG4 value and scanty IgG4-positive plasma cell infiltration in each organ. This case suggests that a condition closely mimicking IgG4-RD may develop without IgG4-positive plasma cells and those exceptional cases should also be taken into account in the differential diagnosis of IgG4-RD.