Geometric control and modeling of genome reprogramming. Issue 4 (3rd July 2016)

• Record Type: Journal Article
• Authors: Uhler, Caroline; Shivashankar, G.V.
• Is Part Of: BioArchitecture. Volume 6:Issue 4(2016)
• Page Start: 76
• Page End: 84
• Publication Date: 2016-07-03
• Subjects: cell geometry -- chromosome organization -- gene expression -- nuclear morphology -- sphere packing models; Cytology -- Periodicals; Cytoarchitectonics -- Periodicals; 571.6
• DOI: 10.1080/19490992.2016.1201620
• Languages: English
• ISSNs: 1949-0992

Abstract

ABSTRACT: Cell geometry is tightly coupled to gene expression patterns within the tissue microenvironment. This perspective synthesizes evidence that the 3D organization of chromosomes is a critical intermediate for geometric control of genomic programs. Using a combination of experiments and modeling we outline approaches to decipher the mechano-genomic code that governs cellular homeostasis and reprogramming.