A case of amyloid deposition in salivary glands with malignant lymphoma. Issue 5 (September 2016) - Ozawa, Michiko
Abstract: The patient was a 69-year-old woman. She initially consulted our institute with a chief complaint of swelling in bilateral submandibular glands and dry mouth. A localized, movable hard elastic mass was observed in bilateral submandibular and parotid glands. Oral dryness and atrophy of the lingual papilla were observed. The patient had a history of malignant lymphoma (mucosa-associated lymphoid tissue (MALT) lymphoma), for which she had undergone two courses of CHOP therapy (cyclophosphamide, doxorubicin, vincristine, and prednisone) in addition to radiotherapy at 48 years of age. Biopsy of the submandibular gland was performed in our department. The extracted submandibular gland was accompanied by elastic, hard induration. Amyloid deposition accompanying lymphocytic infiltration was histopathologically observed from the submandibular gland.