A systematic review and meta-analysis of tract-based spatial statistics studies regarding attention-deficit/hyperactivity disorder. (September 2016)

• Record Type: Journal Article
• Authors: Chen, Lizhou; Hu, Xinyu; Ouyang, Luo; He, Ning; Liao, Yi; Liu, Qi; Zhou, Ming; Wu, Min; Huang, Xiaoqi; Gong, Qiyong
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 68(2016)
• Page Start: 838
• Page End: 847
• Publication Date: 2016-09
• Subjects: Meta-analysis -- Attention-deficit/hyperactivity disorder -- Diffusion tensor imaging -- Tract-based spatial statistics -- Fractional anisotropy -- Seed-based d mapping; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2016.07.022
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: We qualitatively and quantitatively reviewed the TBSS studies in ADHD. A new approach of seed-based d mapping (SDM) analysis was used. The most robust WM changes were located in CC splenium and right sagittal stratum. Subgroup meta-analyses of non-adult, male and medicated samples were conducted. The age effects may be more pronounced in CC splenium in patients with ADHD. Abstract: Diffusion tensor imaging (DTI) studies that use tract-based spatial statistics (TBSS) have demonstrated the microstructural abnormalities of white matter (WM) in patients with attention-deficit/hyperactivity disorder (ADHD); however, robust conclusions have not yet been drawn. The present study integrated the findings of previous TBSS studies to determine the most consistent WM alterations in ADHD via a narrative review and meta-analysis. The literature search was conducted through October 2015 to identify TBSS studies that compared fractional anisotropy (FA) between ADHD patients and healthy controls. FA reductions were identified in the splenium of the corpus callosum (CC) that extended to the right cingulum, right sagittal stratum, and left tapetum. The first two clusters retained significance in the sensitivity analysis and in all subgroup analyses. The FA reduction in the CC splenium was negatively associated with the mean age of the ADHD group. We hypothesize that, in addition to the fronto-striatal-cerebellar circuit, the disturbed WM matter tracts that integrate the bilateral hemispheres and posterior-brain circuitries play a crucial role in the pathophysiology of ADHD.