An Alkyne Diboration/6π‐Electrocyclization Strategy for the Synthesis of Pyridine Boronic Acid Derivatives. Issue 19 (5th April 2016)

• Record Type: Journal Article
• Authors: Mora‐Radó, Helena; Bialy, Laurent; Czechtizky, Werngard; Méndez, María; Harrity, Joseph P. A.
• Is Part Of: Angewandte Chemie international edition. Volume 55:Issue 19(2016)
• Page Start: 5834
• Page End: 5836
• Publication Date: 2016-04-05
• Subjects: boronic esters -- diboration -- electrocyclic reactions -- nitrogen heterocycles -- synthetic methods; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201601084
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: A new and efficient synthesis of pyridine‐based heteroaromatic boronic acid derivatives is reported through a novel diboration/6π‐electrocyclization strategy. This method delivers a range of functionalized heterocycles from readily available starting materials. Abstract : Get in the ring ! β‐Alkynyl α, β‐unsaturated oximes undergo a alkyne diboration/6π‐electrocyclization sequence to deliver a range of pyridine boronic acid derivatives. The scope of this method to deliver useful heterocyclic products is described.