Anti-biofilm properties of magnesium metal via alkaline pH. Issue 28 (24th February 2015)

• Record Type: Journal Article
• Authors: Qin, Hui; Zhao, Yaochao; Cheng, Mengqi; Wang, Qi; Wang, Qiaojie; Wang, Jiaxing; Jiang, Yao; An, Zhiquan; Zhang, Xianlong
• Is Part Of: RSC advances. Volume 5:Issue 28(2015)
• Page Start: 21434
• Page End: 21444
• Publication Date: 2015-02-24
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra00027k
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Mg prevents bacteria biofilm formation via high alkalinity at its surface rather than by high Mg ion concentration. Abstract : Prevention of implant-associated infection (IAI) by inhibiting biofilm formation on implants is crucial to orthopedic surgery. In this work, the anti-biofilm activity of magnesium (Mg) is assessed using Pseudomonas aeruginosa ( P. aeruginosa ) and Staphylococcus epidermidis ( S. epidermidis ), two biofilm producing strains, in vitro, and using S. epidermidis in vivo . The effects of high Mg 2+ concentration and alkaline pH on biofilm are evaluated in two separate experiments in vitro . Mg shows biofilm resistance proportional to the degradation of Mg in vitro, which is better than that of the corresponding alkaline pH, and high Mg 2+ concentration has no such effect. Microbiological cultures and histological results demonstrate the ability of Mg against bacterial infection to reduce the risk of IAI in vivo . The results demonstrate that Mg prevents bacteria biofilm formation by high alkalinity at its surface rather than by high Mg 2+ concentration, thus providing a promising new strategy for combating IAI.