Cytotoxic trichothecene macrolides from the endophyte fungus Myrothecium roridum. Issue 7 (2nd July 2016)

• Record Type: Journal Article
• Authors: Liu, Hong-Xin; Liu, Wei-Zhen; Chen, Yu-Chan; Sun, Zhang-Hua; Tan, Yu-Zhi; Li, Hao-Hua; Zhang, Wei-Min
• Is Part Of: Journal of Asian natural products research. Volume 18:Issue 7(2016)
• Page Start: 684
• Page End: 689
• Publication Date: 2016-07-02
• Subjects: Myrothecium roridum -- endophytic fungus -- trichothecene macrolide -- cytotoxic activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2015.1134505
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A new cytotoxic roridin-type trichothecene macrolide named epiroridin acid (1 ) and two known compounds epiroridin E (2 ) and mytoxin B (3 ) were isolated from the liquid culture of Myrothecium roridum A553, which was isolated from the medicinal plant Pogostemon cablin . The structure of the new macrolide (1 ) was elucidated by extensive spectroscopic measurements (UV, IR, MS, and 1D and 2D NMR) analyses. All isolated compounds (1–3 ) were evaluated for their cytotoxic activities against SF-268, MCF-7, NCI-H460, and HepG-2 tumor cell lines. The new compound (1 ) exhibited well cytotoxicity against the four selected tumor cell lines.