Severe Achromobacter xylosoxidans infection and loss of sputum bacterial diversity in an adult patient with cystic fibrosis. (August 2016)

• Record Type: Journal Article
• Authors: Talbot, Nick P.; Flight, William G.
• Is Part Of: Paediatric respiratory reviews. Volume 20(2016)Supplement
• Page Start: 27
• Page End: 29
• Publication Date: 2016-08
• Subjects: Cystic fibrosis -- Achromobacter xylosoxidans -- Sputum microbiome -- Cross-infection; Pediatric respiratory diseases -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory Therapy -- Periodicals; Child -- Periodicals; Appareil respiratoire -- Infections, chez l'enfant -- Périodiques; Appareil respiratoire -- Maladies, chez l'enfant -- Périodiques; 618.922
• DOI: 10.1016/j.prrv.2016.06.011
• Languages: English
• ISSNs: 1526-0542

Abstract

Summary: Achromobacter spp. are emerging pathogens in the lungs of patients with cystic fibrosis. We report the case of an adult patient with cystic fibrosis and chronic A. xylosoxidans infection who experienced rapid, progressive clinical deterioration. Metagenomic analysis of the sputum revealed that the airway microbiota was almost entirely dominated by A. xylosoxidans . We review the impact of this organism on lung function and the airway microbiome in cystic fibrosis, and discuss the potential for cross-infection between patients.