A complex game of hide and seek: the search for new antifungals. Issue 7 (25th May 2016)

• Record Type: Journal Article
• Authors: Ngo, Huy X.; Garneau-Tsodikova, Sylvie; Green, Keith D.
• Is Part Of: MedChemComm. Volume 7:Issue 7(2016:Jul.)
• Page Start: 1285
• Page End: 1306
• Publication Date: 2016-05-25
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19
• DOI: 10.1039/c6md00222f
• Languages: English
• ISSNs: 2040-2503

Abstract

Abstract : The identification, location, generation, and isolation of new antifungal compounds from their caches in Nature is examined for the years 2010–2016. Abstract : Fungal infections directly affect millions of people each year. In addition to the invasive fungal infections of humans, the plants and animals that comprise our primary food source are also susceptible to diseases caused by these eukaryotic microbes. The need for antifungals, not only for our medical needs, but also for use in agriculture and livestock causes a high demand for novel antimycotics. Herein, we provide an overview of the most commonly used antifungals in medicine and agriculture. We also present a summary of the recent progress (from 2010–2016) in the discovery/development of new agents against fungal strains of medical/agricultural relevance, as well as information related to their biological activity, their mode(s) of action, and their mechanism(s) of resistance.