The benefits of oxidative stress for tissue repair and regeneration. Issue 3 (2nd July 2016)

• Record Type: Journal Article
• Authors: Serras, Florenci
• Is Part Of: Fly. Volume 10:Issue 3(2017)
• Page Start: 128
• Page End: 133
• Publication Date: 2016-07-02
• Subjects: Drosophila -- JNK -- oxidative stress -- p38 -- regeneration -- ROS; Drosophila -- Periodicals; 595.77
• DOI: 10.1080/19336934.2016.1188232
• Languages: English
• ISSNs: 1933-6934

Abstract

ABSTRACT: Recent work has strengthened Drosophila imaginal discs as a model system for regeneration studies. Evidence is accumulating that oxidative stress drives the cellular responses for repair and regeneration. Drosophila imaginal discs generate a burst of reactive oxygen species (ROS) upon damage that is necessary for the activation of the Jun N-terminal kinase (JNK) and p38 MAP kinase signaling pathways. Moreover, these pathways are pivotal in the activation of regenerative growth. A hypothetical mechanism of how the ROS are initiated, and how repair and regeneration is activated is discussed here.