Developing Precisely Defined Drug‐Loaded Nanoparticles by Ring‐Opening Polymerization of a Paclitaxel Prodrug. Issue 15 (25th April 2016)

• Record Type: Journal Article
• Authors: Liu, Jinyao; Pang, Yan; Bhattacharyya, Jayanta; Liu, Wenge; Weitzhandler, Isaac; Li, Xinghai; Chilkoti, Ashutosh
• Is Part Of: Advanced healthcare materials. Volume 5:Issue 15(2016)
• Page Start: 1868
• Page End: 1873
• Publication Date: 2016-04-25
• Subjects: anticancer -- nanoparticle -- paclitaxel -- prodrug -- ring‐opening polymerization; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201600230
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Nanoparticles with high paclitaxel (PTX) loading and low systemic toxicity are prepared in scalable and versatile manner via one‐step ring‐opening polymerization of a prodrug monomer consisting of PTX that is appended to a cyclic carbonate through a hydrolysable ester linker. Initiating this monomer from a hydrophilic macroinitiator results in an amphiphilic diblock copolymer that spontaneously self‐assembles into well‐defined nanoparticles with tunable size.