915 nm Light‐Triggered Photodynamic Therapy and MR/CT Dual‐Modal Imaging of Tumor Based on the Nonstoichiometric Na0.52YbF3.52:Er Upconversion Nanoprobes. Issue 31 (23rd June 2016)

• Record Type: Journal Article
• Authors: Huang, Yanan; Xiao, Qingbo; Hu, Huishan; Zhang, Kunchi; Feng, Yamin; Li, Fujin; Wang, Jian; Ding, Xianguang; Jiang, Jiang; Li, Yanfang; Shi, Liyi; Lin, Hongzhen
• Is Part Of: Small. Volume 12:Issue 31(2016)
• Page Start: 4200
• Page End: 4210
• Publication Date: 2016-06-23
• Subjects: 915 nm -- bioimaging -- photodynamic therapy -- upconversion nanoparticles; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201601023
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Lanthanide (Ln 3+ )‐doped upconversion nanoparticles (UCNPs) as a new generation of multimodal bioprobes have attracted great interest for theranostic purpose. Herein, red emitting nonstoichiometric Na0.52 YbF3.52 :Er UCNPs of high luminescence intensity and color purity are synthesized via a facile solvothermal method. The red UC emission from the present nanophosphors is three times more intense than the well‐known green emission from the ≈30 nm sized hexagonal‐phase NaYF4 :Yb, Er UCNPs. By utilizing Na0.52 YbF3.52 :Er@SrF2 UCNPs as multifunctional nanoplatforms, highly efficient in vitro and in vivo 915 nm light‐triggered photodynamic therapies are realized for the first time, with dramatically diminished overheating yet similar therapeutic effects in comparison to those triggered by 980 nm light. Moreover, by virtue of the high transverse relaxivity ( r 2 ) and the strong X‐ray attenuation ability of Yb 3+ ions, these UCNPs also demonstrate good performances as contrast agents for high contrast magnetic resonance and X‐ray computed tomography dual‐modal imaging. Our research shows the great potential of the red emitting Na0.52 YbF3.52 :Er UCNPs for multimodal imaging‐guided photodynamic therapy of tumors. Abstract : Nonstoichiometric Na0.52 YbF3.52 :Er nanoprobes are synthesized via a facile solvothermal method, showing selectively increased red upconversion luminescence because of successful local structure engineering. By virtue of the high luminescence property of these nanoprobes under 915 nm light excitation, efficient photodynamic therapy of tumors with limited overheating is achieved. Moreover, high contrast MR and CT bioimaging are also realized based on this multifunctional material, indicating their great potential as multiplex theranostic nanoplatforms.