IFN-β differentially regulates the function of T cell subsets in MS and EAE. (August 2016)

• Record Type: Journal Article
• Authors: Kavrochorianou, Nadia; Markogiannaki, Melina; Haralambous, Sylva
• Is Part Of: Cytokine & growth factor reviews. Volume 30(2016)
• Page Start: 47
• Page End: 54
• Publication Date: 2016-08
• Subjects: APC antigen-presenting cell -- BBB blood-brain barrier -- CCR C-C chemokine receptor -- CNS central nervous system -- CSF cerebrospinal fluid -- CXCR C-X-C chemokine receptor -- EAE experimental autoimmune encephalomyelitis -- FoxA forkhead box protein A -- FOXP3 forkhead box P3 -- GITRL glucocorticoid-induced TNF receptor-related protein -- IFN interferon -- IFNAR interferon receptor -- IL interleukin -- IRF interferon regulatory factor -- LN lymph nodes -- MBP myelin basic protein -- MIP macrophage inflammatory protein -- MMP9 metalloproteinase-9 -- MOG myelin oligodendrocyte glycoprotein -- MS multiple sclerosis -- NAb neutralizing antibody -- NMO neuromyelitis optica -- PAMP pathogen-associated molecular pattern -- PBMC peripheral blood mononuclear cell -- pDC plasmacytoid dendritic cell -- PD-L programmed death-ligand -- PLP proteolipid protein -- PRR pathogen recognition receptor -- SOCS suppressor of cytokine signaling -- STAT signal transducer and activator of transcription -- Tfh T follicular helper cell -- Tfr T follicular regulatory cell -- Th T helper cell -- TNF tumor necrosis factor -- Tr1 type 1 regulatory cells -- Treg T regulatory cell -- USP18 Ubiquitin specific peptidase 18 -- VLA4 very late antigen 4; Multiple sclerosis -- Interferon beta -- T cell subsets -- Inflammation -- Experimental Autoimmune Encephalomyelitis; Cytokines -- Periodicals; 571.84
• DOI: 10.1016/j.cytogfr.2016.03.013
• Languages: English
• ISSNs: 1359-6101

Abstract

Highlights: T cell targeting therapies in MS act either directly or indirectly. Endogenous and exogenous IFN-β regulate pro- and anti-inflammatory responses. IFN-β differentially affects T cell subsets involved in MS and EAE. Homeostatic functions of IFN-β are disease staging and setting context-dependent. Abstract: Multiple sclerosis (MS) is considered as a T cell mediated autoimmune disease of the CNS, although a pathogenic role has also been attributed to other immune cell types as well as to environmental and genetic factors. Considering that T cells are interesting from an immunopathogenic point of view and consequently from a therapeutic perspective, various T cell targeted therapies have been approved for MS. Interferon beta (IFN-β) is widely used as first-line intervention for modulating T cell responses, although its pleiotropic and multifaceted activities influence its effectiveness on the disease development, with mechanisms that are not yet fully understood. Since different T cell populations, including pro-inflammatory and regulatory T cells, might affect the course of MS, the effects of IFN-β become even more complex. This review will summarize recent findings regarding the T cell targeted effect of IFN-β in MS and its animal model EAE, with emphasis on the direct actions of endogenous and exogenous IFN-β on each T cell subpopulation involved in CNS autoimmunity. Delineating how IFN-β exerts its action on different T cell types may eventually contribute to the designing of therapeutic strategies aiming to improve the effectiveness of this drug for MS treatment.