Whole-brain mapping of afferent projections to the bed nucleus of the stria terminalis in tree shrews. (1st October 2016)

• Record Type: Journal Article
• Authors: Ni, Rong-Jun; Luo, Peng-Hao; Shu, Yu-Mian; Chen, Ju-Tao; Zhou, Jiang-Ning
• Is Part Of: Neuroscience. Volume 333(2016)
• Page Start: 162
• Page End: 180
• Publication Date: 2016-10-01
• Subjects: prefrontal cortex -- amygdala -- hypothalamus -- hippocampus -- ventral tegmental area -- parabrachial nucleus; 2 layer 2 of cortex -- 3 layer 3 of cortex -- 10N dorsal motor nucleus of vagus -- 12n root of hypoglossal nerve -- 12N hypoglossal nucleus -- 3N oculomotor nucleus -- 3PC oculomotor nucleus, parvicellular part -- 3V 3rd ventricle -- 4n trochlear nerve -- 4N trochlear nucleus -- 4V 4th ventricle -- 6n root of abducens nerve -- 6N abducens nucleus -- 7N facial nucleus -- 7n facial nerve -- 8cn cochlear root of the vestibulocochlear nerve -- 8vn vestibular root of the vestibulocochlear nerve -- AA anterior amygdaloid area -- Ab auditory belt area -- AB accessory basal nucleus -- Ac auditory core area -- ac anterior commissure -- Acb accumbens nucleus -- AcbC accumbens nucleus, core -- AcbSh accumbens nucleus, shell -- aci anterior commissure, intrabulbar part -- ACo anterior cortical amygdaloid nucleus -- acp anterior commissure, posterior part -- AD anterodorsal thalamic nucleus -- AHi amygdalohippocampal area -- AHy anterior hypothalamic area -- alv alveus of the hippocampus -- AM anteromedial thalamic nucleus -- Amb ambiguus nucleus -- AmbC ambiguus nucleus, compact part -- AOD anterior olfactory nucleus, dorsal part -- AOE anterior olfactory nucleus, external part -- AOL anterior olfactory nucleus, lateral part -- AOM anterior olfactory nucleus, medial part -- AOV anterior olfactory nucleus, ventral part -- AP area postrema -- APT anterior pretectal nucleus -- APTD anterior pretectal nucleus, dorsal part -- APTV anterior pretectal nucleus, ventral part -- Aq aqueduct -- Arc arcuate hypothalamic nucleus -- ArcP arcuate hypothalamic nucleus, posterior part -- ASt amygdalostriatal transition area -- AV anteroventral thalamic nucleus -- B brachium of the superior colliculus -- BLA basolateral amygdaloid nucleus -- BMA basomedial amygdaloid nucleus -- BST bed nucleus of the stria terminalis -- CA1 field CA1 of the hippocampus -- CA2 field CA2 of the hippocampus -- CA3 field CA2 of the hippocampus -- cc corpus callosum -- CC central canal -- Cd caudate nucleus -- CeA central amygdaloid nucleus -- Cg cingulate cortex -- CG central gray -- Cl claustrum -- CLi caudal linear nucleus of the raphe -- CM central medial thalamic nucleus -- CnF cuneiform nucleus -- cp cerebral peduncle -- csc commissure of the superior colliculus -- Cu cuneate nucleus -- cu cuneate fasciculus -- D3V dorsal 3rd ventricle -- das dorsal acoustic stria -- DCN dorsal cochlear nucleus -- DFC dorsal frontal cortex -- DG dentate gyrus of the hippocampus -- DLG dorsal lateral geniculate nucleus -- DMH dorsomedial hypothalamic nucleus -- DpG deep gray layer of the superior colliculus -- DpWh deep white layer of the superior colliculus -- DR dorsal raphe nucleus -- DS dorsal subiculum -- dsc dorsal spinocerebellar tract -- DTg dorsal tegmental nucleus -- dtgx dorsal tegmental decussation -- E ependyma and subependymal layer -- EA sublenticular extended amygdala -- EAC sublenticular extended amygdala, central part -- Ect ectorhinal cortex -- ECu external cuneate nucleus -- EGP external globus pallidus -- Ent entorhinal cortex -- EPl external plexiform layer of the olfactory bulb -- EPlA external plexiform layer of the accessory olfactory bulb -- EW Edinger-Westphal nucleus -- f fornix -- FG Fluoro-Gold -- fi fimbria of the hippocampus -- fmi forceps minor of the corpus callosum -- fr fasciculus retroflexus -- g7 genu of the facial nerve -- GCL granule cell layer of the olfactory bulb -- Gem gemini hypothalamic nucleus -- Gi gigantocellular reticular nucleus -- GL glomerular layer of the olfactory bulb -- GlA glomerular layer of the accessory olfactory bulb -- Gr gracile nucleus -- GrA granule cell layer of the accessory olfactory bulb -- GrDG granular layer of the dentate gyrus -- Hip hippocampus -- IAM interanteromedial thalamic nucleus -- ic internal capsule -- IC inferior colliculus -- ICj islands of Calleja -- icp inferior cerebellar peduncle -- IF interfascicular nucleus -- IG indusium griseum -- IGL intergeniculate leaf -- IGP internal globus pallidus -- IL infralimbic cortex -- IM intercalated amygdaloid nucleus, main part -- IMD intermediodorsal thalamic nucleus -- InC interstitial nucleus of Cajal -- InG intermediate gray layer of the superior colliculus -- Ins insular cortex -- Int interposed cerebellar nucleus -- InWh intermediate white layer of the superior colliculus -- IO inferior olive -- IPA interpeduncular nucleus, apical subnucleus -- IPAC interstitial nucleus of the posterior limb of the anterior commissure -- IPC interpeduncular nucleus, caudal subnucleus -- IPl internal plexiform layer of the olfactory bulb -- IPL interpeduncular nucleus, lateral subnucleus -- IPR interpeduncular nucleus, rostral subnucleus -- IRd infraradiata dorsalis -- IRt intermediate reticular nucleus -- IRv infraradiata ventral area -- IT inferior temporal cortex -- Lat lateral cerebellar nucleus -- LC locus coeruleus -- LD laterodorsal thalamic nucleus -- LDTg laterodorsal tegmental nucleus -- lfp longitudinal fasciculus of the pons -- LHA lateral hypothalamic area -- LHb lateral habenular nucleus -- LHbL lateral habenular nucleus, lateral part -- LHbM lateral habenular nucleus, medial part -- LL nucleus of the lateral lemniscus -- ll lateral lemniscus -- LM lateral mammillary nucleus -- LMoL lacunosum moleculare layer of the hippocampus -- lo lateral olfactory tract -- LOT nucleus of the lateral olfactory tract -- LPB lateral parabrachial nucleus -- LPO lateral preoptic area -- LRt lateral reticular nucleus -- LSd lateral septal nucleus, dorsal part -- LSi lateral septal nucleus, intermediate part -- LSS lateral stripe of the striatum -- LSv lateral septal nucleus, ventral part -- LV lateral ventricle -- M1 primary motor cortex -- M2 secondary motor cortex -- MCL mitral cell layer of the olfactory bulb -- mcp middle cerebellar peduncle -- MD mediodorsal thalamic nucleus -- MdD medullary reticular nucleus, dorsal part -- MdV medullary reticular nucleus, ventral part -- ME median eminence -- me5 mesencephalic trigeminal tract -- Me5 mesencephalic trigeminal nucleus -- MeA medial amygdaloid nucleus -- Med medial cerebellar nucleus -- MFC medial frontal cortex -- MG medial geniculate nucleus -- MGD medial geniculate nucleus, dorsal part -- MGV medial geniculate nucleus, ventral part -- MHb medial habenular nucleus -- MiA mitral cell layer of the accessory olfactory bulb -- MiTg microcellular tegmental nucleus -- ml medial lemniscus -- ML medial mammillary nucleus, lateral part -- mlf medial longitudinal fasciculus -- mlx medial lemniscus decussation -- MM medial mammillary nucleus, medial part -- MnR median raphe nucleus -- MoDG molecular layer of the dentate gyrus -- MPA medial preoptic area -- MPB medial parabrachial nucleus -- MPO medial preoptic nucleus -- MPT medial pretectal nucleus -- MRe mammillary recess of the 3rd ventricle -- mRt mesencephalic reticular formation -- MS medial septal nucleus -- mt mammillothalamic tract -- MT medial terminal nucleus of the accessory optic tract -- Mx matrix region of the medulla -- NDB nucleus of the diagonal band -- oc olivocerebellar tract -- oc/dsc olivocerebellar tract and dorsal spinocerebellar tract -- och optic chiasm -- OFC orbital frontal cortex -- ONL olfactory nerve layer -- Op optic nerve layer of the superior colliculus -- opt optic tract -- OPT olivary pretectal nucleus -- Or oriens layer of the hippocampus -- OV olfactory ventricle (olfactory part of lateral ventricle) -- P5 peritrigeminal zone -- PaA paraventricular hypothalamic nucleus, anterior part -- PAG periaqueductal gray -- PBG parabigeminal nucleus -- PBP parabrachial pigmented nucleus of the VTA -- PBS phosphate-buffered saline -- PC paracentral thalamic nucleus -- Pc central nucleus of the pulvinar -- pc posterior commissure -- PCRt parvicellular reticular nucleus -- Pd dorsal nucleus of the pulvinar -- Pe periventricular hypothalamic nucleus -- PeF perifornical nucleus -- PF parafascicular thalamic nucleus -- PG pineal gland -- PH posterior hypothalamic nucleus -- PHA posterior hypothalamic area -- Pir1 piriform cortex, layer 1 -- PLH peduncular part of lateral hypothalamus -- Pn pontine nuclei -- PN paranigral nucleus of the VTA -- PnC pontine reticular nucleus, caudal part -- PnO pontine reticular nucleus, oral part -- Po posterior complex of the thalamus -- PoDG polymorph layer of the dentate gyrus -- PoMn posteromedian thalamic nucleus -- Post postsubiculum -- pPAG p1 periaqueductal gray -- PPc posterior parietal caudal area -- PPd posterior parietal dorsal area -- PPr posterior parietal rostral area -- Pr prepositus nucleus -- Pr5 principal sensory trigeminal nucleus -- PrC precommissural nucleus -- PrEW pre-Edinger-Westphal nucleus -- PRh perirhinal cortex -- PrL prelimbic cortex -- PrS presubiculum -- pRt p1 reticular formation -- PT paratenial thalamic nucleus -- PTg pedunculopontine tegmental nucleus -- Pu putamen -- Pv ventral nucleus of the pulvinar -- PvA parietal ventral area -- PVA paraventricular thalamic nucleus, anterior part -- PVN paraventricular hypothalamic nucleus -- PVP paraventricular thalamic nucleus, posterior part -- py pyramidal tract -- Py pyramidal cell layer of the hippocampus -- pyx pyramidal decussation -- Rad radiatum layer of the hippocampus -- Rbd rhabdoid nucleus -- Re reuniens thalamic nucleus -- Rh rhomboid thalamic nucleus -- RLi rostral linear nucleus of the raphe -- RMC red nucleus, magnocellular part -- Ro nucleus of Roller -- RPa raphe pallidus nucleus -- RPC red nucleus, parvicellular part -- RRF retrorubral field -- rs rubrospinal tract -- RSg retrosplenial granular cortex -- Rt reticular thalamic nucleus -- RtTg reticulotegmental nucleus of the pons -- S1 primary somatosensory cortex -- S2 secondary somatosensory cortex -- s5 sensory root of the trigeminal nerve -- SCC somatosensory caudal cortex -- SCN suprachiasmatic nucleus -- scp superior cerebellar peduncle -- scpd superior cerebellar peduncle, descending limb -- SFi septofimbrial nucleus -- SFO subfornical organ -- SGe supragenual nucleus -- SHi septohippocampal nucleus -- SHy septohypothalamic nucleus -- sm stria medullaris of the thalamus -- SNC substantia nigra, compact part -- SNL substantia nigra, lateral part -- SNR substantia nigra, reticular part -- SO superior olive -- Sol solitary nucleus -- SON supraoptic nucleus -- Sp5 spinal trigeminal nucleus -- sp5 spinal trigeminal tract -- SPTg subpeduncular tegmental nucleus -- SpVe spinal vestibular nucleus -- st stria terminalis -- STh subthalamic nucleus -- StHy striohypothalamic nucleus -- STA bed nucleus of the stria terminalis, anterior part -- STAL bed nucleus of the stria terminalis, anterolateral part -- STAM bed nucleus of the stria terminalis, anteromedial part -- STP bed nucleus of the stria terminalis, posterior part -- STPL bed nucleus of the stria terminalis, posterolateral part -- STPM bed nucleus of the stria terminalis, posteromedial part -- STV bed nucleus of the stria terminalis, ventral part -- str superior thalamic radiation -- Su5 supratrigeminal nucleus -- Sub submedius thalamic nucleus -- SubC subcoeruleus nucleus -- SuG superficial gray layer of the superior colliculus -- SuM supramammillary nucleus -- SuML supramammillary nucleus, lateral part -- SuMM supramammillary nucleus, medial part -- sumx supramammillary decussation -- TC temporal cortex -- tfp transverse fibers of the pons -- TI temporal inferior area -- TS triangular septal nucleus -- tth trigeminothalamic tract -- Tu olfactory tubercle -- Tu1 layer 1 of olfactory tubercle -- tz trapezoid body -- Tz nucleus of the trapezoid body -- V1 primary visual cortex -- V2 secondary visual cortex -- VCA ventral cochlear nucleus, anterior part -- VCN ventral cochlear nucleus -- Ves vestibular nucleus -- VL ventrolateral thalamic nucleus -- VLG ventral lateral geniculate nucleus -- VLN ventrolateral reticular nucleus -- VM ventromedial thalamic nucleus -- VMH ventromedial hypothalamic nucleus -- VP ventral pallidum -- VPM ventral posteromedial thalamic nucleus -- VPO ventral periolivary nucleus -- VPPC ventral posterior nucleus of the thalamus, parvicellular part -- VPT ventral posterior thalamic nucleus -- VS ventral subiculum -- vsc ventral spinocerebellar tract -- VTAR ventral tegmental area, rostral part -- VTg ventral tegmental nucleus -- vtgx ventral tegmental decussation -- VTM ventral tuberomammillary nucleus -- xscp decussation of the superior cerebellar peduncle -- ZI zona incerta -- Zo zonal layer of the superior colliculus; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2016.07.017
• Languages: English
• ISSNs: 0306-4522

Abstract

Graphical abstract: Here we provided density of Fluoro-Gold (FG)-labeled cells in each brain structure of three tree shrews. The color of each box represents the relative density of labeled cells in each brain region, e.g., 0—no FG labeling, 1—sparse, 2—moderate, 3—extensive. Highlights: The first detailed whole-brain mapping of BST-projecting neurons in tree shrews. The BST-projecting regions were firstly identified in the tree shrew brain. The density of BST-projecting neurons in whole-brain regions was analyzed. Abstract: The bed nucleus of the stria terminalis (BST) plays an important role in integrating and relaying input information to other brain regions in response to stress. The cytoarchitecture of the BST in tree shrews ( Tupaia belangeri chinensis ) has been comprehensively described in our previous publications. However, the inputs to the BST have not been described in previous reports. The aim of the present study was to investigate the sources of afferent projections to the BST throughout the brain of tree shrews using the retrograde tracer Fluoro-Gold (FG). The present results provide the first detailed whole-brain mapping of BST-projecting neurons in the tree shrew brain. The BST was densely innervated by the prefrontal cortex, entorhinal cortex, ventral subiculum, amygdala, ventral tegmental area, and parabrachial nucleus. Moreover, moderate projections to the BST originated from the medial preoptic area, supramammillary nucleus, paraventricular thalamic nucleus, pedunculopontine tegmental nucleus, dorsal raphe nucleus, locus coeruleus, and nucleus of the solitary tract. Afferent projections to the BST are identified in the ventral pallidum, nucleus of the diagonal band, ventral posteromedial thalamic nucleus, posterior complex of the thalamus, interfascicular nucleus, retrorubral field, rhabdoid nucleus, intermediate reticular nucleus, and parvicellular reticular nucleus. In addition, the different densities of BST-projecting neurons in various regions were analyzed in the tree shrew brains. In summary, whole-brain mapping of direct inputs to the BST is delineated in tree shrews. These brain circuits are implicated in the regulation of numerous physiological and behavioral processes including stress, reward, food intake, and arousal.